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Functions of the Lymphatic and Immune System01:28

Functions of the Lymphatic and Immune System

3.8K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
3.8K
Renal Corpuscle01:20

Renal Corpuscle

2.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.9K
Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

4.3K
Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
4.3K
Nephrotic Syndrome I : Introduction01:24

Nephrotic Syndrome I : Introduction

12
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
12
Nephrons01:10

Nephrons

3.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.1K
Nephrotic Syndrome III : Nursing Management01:24

Nephrotic Syndrome III : Nursing Management

21
Nursing management for nephrotic syndrome adapts as the disease progresses, with strategies evolving to address advancing symptoms and complications.Early-Stage Management In the early stages, nursing interventions for nephrotic syndrome resemble those used in managing acute glomerulonephritis, focusing on symptom monitoring, fluid balance, and managing mild to moderate edema.Vital Signs: Regularly monitor blood pressure, pulse, respiratory rate, and temperature to promptly identify...
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Related Experiment Video

Updated: Aug 4, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

3.0K

The Lymphatic System in Kidney Disease.

Megan L Baker1, Lloyd G Cantley

  • 1Section of Nephrology, Yale School of Medicine, New Haven, Connecticut.

Kidney360
|April 5, 2023
PubMed
Summary

The lymphatic system removes fluid and supports immune function. In kidney disease, new lymphatic vessel growth (lymphangiogenesis) may be harmful, suggesting a potential therapeutic target.

Area of Science:

  • Renal physiology and immunology
  • Lymphatic system function
  • Kidney disease pathogenesis

Background:

  • The lymphatic system is crucial for fluid balance, macromolecule clearance, and immune surveillance throughout the body.
  • Kidney lymphatics maintain renal function and shape organ-specific immunity.
  • Kidney diseases often increase the burden on lymphatic networks, leading to lymphangiogenesis.

Purpose of the Study:

  • To explore the role of the lymphatic system in kidney health and disease.
  • To investigate the impact of lymphangiogenesis in acute kidney injury (AKI) and chronic kidney disease (CKD).
  • To assess the potential of targeting lymphatics for therapeutic interventions in kidney disorders.

Main Methods:

  • Review of existing literature on lymphatic system function in the kidney.

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Last Updated: Aug 4, 2025

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
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Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
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  • Analysis of evidence linking lymphangiogenesis to kidney injury and allograft rejection.
  • Exploration of the dual role of lymphatics in kidney homeostasis and disease.
  • Main Results:

    • Lymphangiogenesis is frequently observed in AKI, CKD, and kidney transplantation.
    • Emerging evidence suggests lymphangiogenesis may be detrimental in AKI and kidney allograft rejection.
    • The precise role of lymphangiogenesis in kidney protection versus maladaptation requires further investigation.

    Conclusions:

    • The lymphatic system is an active participant in kidney physiology and pathology.
    • Lymphangiogenesis in the kidney may represent a therapeutic target, but its precise role is complex and context-dependent.
    • Further research is needed to elucidate the protective versus harmful effects of lymphangiogenesis in various kidney disease settings.