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Updated: Aug 4, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
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LncRNA RP11-1100L3.8 Involves in the Pathogenesis of Multiple Myeloma by Regulating NR4A1

Youfan Feng1,2, Xiaofang Wei2, Yuan Fu2

  • 1The First Clinical Medical College of Lanzhou University, 730000 Lanzhou, Gansu, China.

Discovery Medicine
|April 6, 2023
PubMed
Abstract

Insights

This study identifies RP11-1100L3.8 as a novel biomarker for multiple myeloma (MM). It regulates the NR4A1-mediated PI3K-AKT pathway, impacting MM cell proliferation and apoptosis.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Long non-coding RNAs (lncRNAs) play roles in multiple myeloma (MM) pathogenesis.
  • The specific lncRNA profile and functional lncRNAs in MM require further elucidation.

Purpose of the Study:

  • To identify and characterize novel functional lncRNAs in multiple myeloma (MM).
  • To investigate the regulatory network and potential biomarkers for MM.

Main Methods:

  • RNA-sequencing (RNAseq) was employed to analyze lncRNA and mRNA expression patterns in MM.
  • Differentially expressed genes were identified, and a regulatory network was constructed.
  • In vitro experiments were conducted to validate the functional roles of identified lncRNAs and their targets.

Main Results:

  • 539 differentially expressed lncRNAs were identified, with RP11-1100L3.8 being the most upregulated.
  • RP11-1100L3.8 was positively correlated with NR4A1, a key mRNA implicated in poor MM prognosis.
  • RP11-1100L3.8 downregulation inhibited MM cell proliferation and promoted apoptosis by regulating the PI3K-AKT signaling pathway.

Conclusions:

  • RP11-1100L3.8 is a potential biomarker for MM and may regulate MM pathophysiology via the NR4A1-mediated PI3K-AKT pathway.
  • This study offers a novel biomarker candidate for therapeutic strategies in MM.
Keywords:
biomarkerlncRNAmultiple myelomaprecise therapy

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