Related Experiment Video
Updated: Aug 3, 2025

A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
BICePs v2.0: Software for Ensemble Reweighting Using Bayesian Inference of Conformational Populations
Robert M Raddi1, Yunhui Ge2, Vincent A Voelz1
1Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, United States.
Abstract:
Bayesian Inference of Conformational Populations (BICePs) version 2.0 (v2.0) is a free, open-source Python package that reweights theoretical predictions of conformational state populations using sparse and/or noisy experimental measurements. In this article, we describe the implementation and usage of the latest version of BICePs (v2.0), a powerful, user-friendly and extensible package which makes several improvements upon the previous version. The algorithm now supports many experimental NMR observables (NOE distances, chemical shifts, J-coupling constants, and hydrogen-deuterium exchange protection factors), and enables convenient data preparation and processing. BICePs v2.0 can perform automatic analysis of the sampled posterior, including visualization, and evaluation of statistical significance and sampling convergence. We provide specific coding examples for these topics, and present a detailed example illustrating how to use BICePs v2.0 to reweight a theoretical ensemble using experimental measurements.
More Related Videos
06:45Dissecting Multi-protein Signaling Complexes by Bimolecular Complementation Affinity Purification BiCAP
Published on: June 15, 2018
04:58Author Spotlight: Investigating the Role of Repetitive DNA Misregulation in Cancer Initiation and Immunotherapy Resistance
Published on: December 13, 2024
Related Concept Videos
One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation
On...
Weighted Mean
For example, consider the number of goals scored in the matches of a tournament. While computing the average number of goals scored in the tournament, it may be more important to...
Protein Folding Quality Check in the RER
Distributions to Estimate Population Parameter
Instrument Calibration
Analytical Balance Calibration
An analytical balance measures mass and requires regular calibration to...
Estimation of the Physical Quantities