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Interstitial Lung Disease: How Should Therapeutics Be Implemented?

Cosimo Bruni1, Corrado Campochiaro2, Jeska K de Vries-Bouwstra3

  • 1Department of Rheumatology, University Hospital Zurich, University of Zurich, Schmelzbergstrasse 24, Zurich 8006, Switzerland; Division of Rheumatology, Department of Experimental Medicine, Careggi University Hospital - University of Florence, Florence, Italy.

Rheumatic Diseases Clinics of North America
|April 7, 2023
PubMed

Systemic sclerosis-interstitial lung disease (SSc-ILD) is a major complication of SSc resulting in important morbidity and mortality. Next to cyclophosphamide and mycophenolate mofetil, tocilizumab and nintedanib have proven efficacy in the treatment of SSc-ILD. The highly variable course of SSc-ILD, the complexity in determining and predicting the progression of SSc-ILD, and the diversity of treatment options for SSc-ILD, pose many challenges for everyday clinical practice. In this review, currently available evidence for monitoring and treatment of SSc-ILD is summarized and areas where additional evidence is highly desirable are discussed.

Keywords:
Combination therapyInterstitial lung diseaseSystemic sclerosisTargeted therapiesTreatment

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