Effects of epigenetic age acceleration on kidney function: a Mendelian randomization study
Yang Pan1, Xiao Sun1,2, Zhijie Huang2
1Division of Nephrology, Department of Medicine, College of Medicine, University of Illinois at Chicago, 820 S Wood Street, Chicago, IL, 60607, USA.
Clinical Epigenetics
|April 8, 2023
Summary
Epigenetic age acceleration (EAA) is linked to reduced kidney function and increased chronic kidney disease (CKD) risk. This study confirms a bidirectional causal relationship between EAA and kidney health.
Area of Science:
- Genetics
- Epigenetics
- Nephrology
Background:
- Cross-sectional studies suggest associations between epigenetic age acceleration (EAA) and kidney function.
- The temporal and causal nature of these relationships requires further investigation.
Approach:
- A bidirectional two-sample Mendelian randomization study was conducted using genetic instruments for EAA and estimated glomerular filtration rate (eGFR).
- Summary-based and allele score-based Mendelian randomization analyses utilized large-scale genome-wide association study (GWAS) meta-analyses data from European-ancestry participants.
Key Points:
- Increased intrinsic EAA (IEAA) and GrimAge acceleration (GrimAA) were associated with decreased log-eGFR.
- Higher IEAA showed increased odds of chronic kidney disease (CKD).
- Decreased kidney function causally influenced HannumAge acceleration (HannumAA), GrimAA, and PhenoAge acceleration (PhenoAA).
Conclusions:
- This study provides evidence for bidirectional causal relationships between EAA and kidney function.
- Findings suggest potential targets for prevention and therapeutic strategies in kidney disease.
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