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Related Experiment Video

Updated: Aug 3, 2025

An In Vitro Dormancy Model of Estrogen-sensitive Breast Cancer in the Bone Marrow: A Tool for Molecular Mechanism Studies and Hypothesis Generation
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Dormancy in Breast Cancer.

Erica Dalla1, Amulya Sreekumar2, Julio A Aguirre-Ghiso3

  • 1Division of Hematology and Oncology, Department of Medicine and Department of Otolaryngology, Department of Oncological Sciences, Black Family Stem Cell Institute, Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA.

Cold Spring Harbor Perspectives in Medicine
|April 10, 2023
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Summary

Delayed breast cancer recurrence may stem from tumor dormancy. This review explores clinical data and mechanistic insights to understand dormancy and guide interventions for high-risk patients.

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Area of Science:

  • Oncology
  • Cancer Biology
  • Translational Research

Background:

  • Delayed recurrence in breast cancer suggests a period of dormancy.
  • Understanding dormancy is crucial for managing high-risk patients.

Purpose of the Study:

  • To develop a framework for identifying breast cancer dormancy in clinical settings.
  • To integrate clinical data with mechanistic insights into dormancy.
  • To propose interventions for managing recurrence risk.

Main Methods:

  • Critical evaluation of existing clinical data on breast cancer recurrence.
  • Integration of data from genetically engineered mouse models and experimental metastasis models.
  • Review of mechanistic insights into tumor dormancy.

Main Results:

  • A framework for inferring dormancy in clinical breast cancer is proposed.
  • Mechanistic understanding of dormancy is enhanced by integrating preclinical data.
  • Actionable interventions and ongoing clinical trials are discussed.

Conclusions:

  • Dormancy is a key factor in delayed breast cancer recurrence.
  • Integrating clinical and preclinical data advances the understanding of dormancy.
  • Translational research offers new strategies for long-term patient management.