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Related Experiment Video

Updated: Aug 3, 2025

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Research Progress on Estimation of Postmortem Interval Based on Ocular Tissues Structure.

Hui Wu1,2, Fang-Fang Liu1, Jun-da Wu3

  • 1Department of Forensic Medicine, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.

Fa Yi Xue Za Zhi
|April 11, 2023
PubMed
Summary
This summary is machine-generated.

Estimating the postmortem interval (PMI) using ocular tissues is crucial in forensic pathology. Changes in the eye

Keywords:
corneaforensic pathologyocular tissuespostmortem intervalreviewvitreous humor

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Area of Science:

  • Forensic Pathology
  • Ocular Toxicology
  • Biomolecular Analysis

Background:

  • Accurate postmortem interval (PMI) estimation is vital in forensic investigations.
  • Ocular tissues exhibit reliable time-dependent changes after death.
  • Existing methods for PMI estimation have limitations.

Approach:

  • Reviewing research on morphological changes in ocular tissues (cornea, lens, vitreous humor, etc.).
  • Analyzing biochemical and molecular alterations within ocular structures.
  • Exploring genetic material changes for PMI determination.

Key Points:

  • Corneal opacity, aqueous humor analysis, and lens changes correlate with PMI.
  • Vitreous humor potassium levels and biochemical markers offer PMI insights.
  • Retinal and iris changes also provide temporal information.
  • Morphological, biochemical, molecular, and genetic approaches are evaluated.

Conclusions:

  • Ocular tissues provide a promising avenue for postmortem interval estimation.
  • Further research is needed to refine methods and address existing challenges.
  • Integration of multiple ocular markers may improve PMI accuracy.