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Selenium nanoparticles: Properties, preparation methods, and therapeutic applications.

Xiang Xiao1, Huan Deng1, Xue Lin1

  • 1School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, 710061, PR China.

Chemico-Biological Interactions
|April 12, 2023
PubMed
Summary
This summary is machine-generated.

Selenium nanoparticles (SeNPs) offer versatile therapeutic potential in biomedicine. This review highlights their varied bioactivity, drug delivery capabilities, and efficacy across diseases like cancer and diabetes.

Keywords:
Biological propertiesBiomedical applicationsMechanismPreparation methodsSelenium nanoparticlesToxicity

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Area of Science:

  • Biomedical Nanotechnology
  • Materials Science
  • Pharmacology

Background:

  • Selenium nanoparticles (SeNPs) are nano-sized elemental selenium with emerging biomedical applications.
  • SeNP properties are tunable based on fabrication methods, influencing their bioactivity.
  • SeNPs possess excellent biological and physical properties for therapeutic use.

Purpose of the Study:

  • To review the bioactivity of SeNPs synthesized via different methods.
  • To discuss the therapeutic effects and mechanisms of SeNPs in various diseases.
  • To emphasize the significance of SeNP development in medicine.

Main Methods:

  • Literature review of studies on selenium nanoparticle synthesis and characterization.
  • Analysis of research on SeNP therapeutic applications and mechanisms of action.
  • Synthesis of information regarding SeNP drug delivery capabilities.

Main Results:

  • Fabrication methods significantly alter SeNP bioactivity and properties.
  • SeNPs demonstrate therapeutic effects in cancer, inflammation, neurodegenerative diseases, diabetes, reproductive, and cardiovascular diseases.
  • SeNPs function effectively as carriers for therapeutic substances, enhancing drug efficacy.

Conclusions:

  • Selenium nanoparticles exhibit diverse therapeutic potential and tunable properties.
  • SeNPs are promising for treating a wide range of diseases and as drug delivery systems.
  • Further development of SeNPs is crucial for advancing biomedical applications.