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Glycemic Control in Critically Ill COVID-19 Patients: Systematic Review and Meta-Analysis
Subhash Chander1, Vishal Deepak2, Roopa Kumari3
1Department of Internal Medicine, Mount Sinai Beth Israel, New York, NY 10003, USA.
Journal of Clinical Medicine
|April 13, 2023
Summary
Poor glycemic control in COVID-19 patients significantly increases mortality risk and complications. Effective blood glucose management is crucial for improving outcomes in hospitalized patients with hyperglycemia.
Area of Science:
- Critical Care Medicine
- Endocrinology
- Infectious Diseases
Background:
- COVID-19 poses significant mortality risks, particularly for patients with hyperglycemia.
- Evidence suggests improved outcomes with glycemic control, but optimal blood glucose targets remain undefined for critically ill COVID-19 patients.
- Further research is essential to determine effective glycemic control strategies in this population.
Purpose of the Study:
- To evaluate the impact of glycemic control on mortality rates in hospitalized COVID-19 patients.
- To synthesize evidence on blood glucose management strategies for COVID-19 inpatients.
Main Methods:
- Systematic review and meta-analysis adhering to PRISMA guidelines.
- Searched major databases including PubMed, Embase, Cochrane Library, Google Scholar, and ResearchGate.
- Included observational studies comparing glycemic control in COVID-19 patients with and without diabetes.
Main Results:
- Eleven observational studies involving 26,953 patients were analyzed.
- COVID-19 patients with diabetes had a significantly higher incidence of death (OR = 2.70).
- Poor glycemic control was associated with increased mortality (OR = 3.76) and complications (OR = 0.88) in COVID-19 patients.
Conclusions:
- Poor glycemic control in critically ill COVID-19 patients is linked to higher mortality rates.
- Inadequate blood glucose management correlates with increased infection rates, mechanical ventilation use, and prolonged hospital stays.
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