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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Related Experiment Video

Updated: Aug 2, 2025

Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia
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Author Spotlight: Anterior HR-OCT as a Non-Invasive Tool for Characterizing Ocular Surface Squamous Neoplasia

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[The Cutaneous Squamous Cell Carcinoma - An Update].

Birgit Burda1, Erwin S Schultz1

  • 1Klinik für Dermatologie, Klinikum Nürnberg Nord, Nürnberg, Deutschland.

Laryngo- Rhino- Otologie
|April 13, 2023
PubMed
Summary

Cutaneous squamous cell carcinoma (CSCC) treatment is evolving. Cemiplimab, a PD1-antibody, shows promise for advanced CSCC, with ongoing research into new immunotherapies and combination treatments.

Area of Science:

  • Oncology
  • Dermatology

Context:

  • Cutaneous squamous cell carcinoma (CSCC) is a prevalent nonmelanoma skin cancer with rising incidence.
  • High-risk CSCC lesions, including locally advanced or metastatic cases, are associated with significant recurrence and mortality rates.

Purpose:

  • To review current treatment standards for CSCC.
  • To evaluate the efficacy of emerging therapies, such as cemiplimab, for advanced CSCC.
  • To identify future research directions in CSCC treatment.

Summary:

  • Surgical excision is the primary treatment for CSCC.
  • Radiotherapy serves as an alternative for inoperable cases.
  • Cemiplimab, a PD1-antibody, demonstrated a 46% overall response rate in advanced CSCC patients, with survival data pending.

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Cell Population Analyses During Skin Carcinogenesis
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  • Further investigation into immunotherapeutics, combination therapies, and oncolytic viruses is warranted.

    • Impact:

    • Highlights the effectiveness of cemiplimab in advanced CSCC.
    • Emphasizes the need for multidisciplinary approaches in managing advanced CSCC.
    • Suggests future therapeutic strategies will focus on novel immunotherapies and combination treatments for improved patient outcomes.