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Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation
08:04

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[Measles morbidity among children inoculated against this infection]

V M Bolotovskiĭ, B G Gelikman, I V Mikheev

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |March 1, 1986
    PubMed

    Insights

    Measles immunity wanes in some children post-vaccination. School-aged children, even if vaccinated, face higher measles risk due to close contact, not solely decreased immunity.

    Area of Science:

    • Immunology
    • Epidemiology
    • Pediatrics

    Context:

    • Measles vaccination is crucial for public health.
    • Serological surveys assess vaccine effectiveness and population immunity.
    • Understanding measles transmission dynamics in vaccinated populations is essential.

    Purpose:

    • To evaluate measles immunity levels in vaccinated children.
    • To determine the incidence of measles in seronegative and seropositive vaccinated children.
    • To investigate factors contributing to measles breakthrough infections in immunized individuals.

    Summary:

    • A serological survey identified 14.2% of 2009 measles-vaccinated children as seronegative.
    • Over 11 years, seronegative children had significantly higher measles incidence (59.5%) than seropositive ones (0.15%).
    • Booster immunization reduced measles cases in seronegative children to 1.2%. Increased school-aged morbidity is linked to school environments and contact rates, not solely waning immunity.

    Impact:

    • Highlights the importance of serological testing to identify non-immune individuals.
    • Suggests booster immunizations may be beneficial for seronegative populations.
    • Informs public health strategies for measles control, emphasizing environmental and social factors in transmission.

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