Quantitative evaluation of anisometropic amblyopia treatment efficacy by coupling multiple visual functions via...

Area of Science:

• Ophthalmology
• Vision Science

Background:

• Effective amblyopia treatment evaluation is crucial for prevention, control, and rehabilitation.
• Current methods may not fully capture treatment efficacy.
• Developing precise, quantitative measures is essential.

Purpose of the Study:

• To develop a more precise and quantitative method for evaluating amblyopia treatment efficacy.
• To explore the correlation between visual acuity and other visual functions post-treatment.
• To establish a comprehensive index for representing treatment outcomes.

Main Methods:

• Recorded four visual function examination results: visual acuity, binocular rivalry balance point (BRBP), perceptual eye position (PEP), and stereopsis.
• Assessed these functions before and after amblyopia treatment.
• Applied the Criteria Importance Through Inter-criteria Correlation (CRITIC) method to objectively weight and couple the four indexes.

Main Results:

• All four visual function measures showed significant differences before and after treatment.
• Visual acuity improvement did not strongly correlate with changes in BRBP, PEP, and stereopsis.
• The CRITIC-based coupled index demonstrated good performance on a validation dataset, offering a more comprehensive efficacy measure.

Conclusions:

• The proposed coupling method using the CRITIC algorithm and multiple visual function results offers a potential means to quantify amblyopia treatment efficacy.
• This approach provides a more objective and comprehensive evaluation than relying solely on visual acuity.
• The findings support the use of this novel index in clinical practice and research for amblyopia management.