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Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

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The pathophysiology of pneumonia involves the following steps:
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COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

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Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
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Acute Respiratory Failure-I01:21

Acute Respiratory Failure-I

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Acute respiratory failure is a condition characterized by the inability of the lungs to perform their primary function: gas exchange. This failure leads to insufficient oxygen levels (hypoxemia) in the blood, elevated carbon dioxide levels (hypercapnia), or both, causing critical impairment in organ function.
Definition: It is defined by specific criteria based on blood gas measurements. Hypoxemia happens when the partial pressure of oxygen (PaO2) falls below 60 mmHg. At the same time,...
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Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

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Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
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Asthma: Pathogenesis and Management01:20

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Pneumonia I: Introduction01:30

Pneumonia I: Introduction

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Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
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Related Experiment Video

Updated: Aug 2, 2025

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Acute Viral Bronchiolitis: A Narrative Review.

Suresh K Angurana1, Vijai Williams2, Lalit Takia1

  • 1Division of Pediatric Critical Care, Department of Pediatrics, Advanced Pediatrics Centre, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Journal of Pediatric Intensive Care
|April 21, 2023
PubMed
Summary

Acute viral bronchiolitis (AVB) management focuses on supportive care like oxygen and hydration. Some interventions like nebulized adrenaline, hypertonic saline, and non-invasive ventilation show promise, while others are not recommended.

Keywords:
HFNChypertonic salinenebulizationrespiratory syncytial viruswheezing

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Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Respiratory Medicine

Background:

  • Acute viral bronchiolitis (AVB) is a primary cause of infant hospitalizations, leading to significant morbidity and healthcare costs.
  • Effective management strategies for AVB are crucial for improving infant outcomes and reducing healthcare burdens.

Purpose of the Study:

  • To provide clinicians with evidence-based guidance for managing AVB, synthesizing research from the past decade.
  • To review the current understanding of AVB etiology, diagnosis, treatment, and prevention.

Main Methods:

  • A comprehensive literature search was conducted in the PubMed and Cochrane Database of Systematic Reviews for English literature published in the last 10 years.
  • The review focused on studies related to the etiology, diagnosis, treatment, and prevention of AVB.

Main Results:

  • Respiratory syncytial virus is the most common cause of AVB; diagnosis is primarily clinical, with limited utility of investigations and routine chest radiographs.
  • Supportive care, including humidified oxygen and hydration, is the cornerstone of management. Pulse oximetry aids oxygen administration.
  • Beneficial interventions identified include nebulized adrenaline, hypertonic saline, high-flow nasal cannula (HFNC), continuous positive airway pressure (CPAP), non-invasive ventilation (NIV), and surfactant therapy.

Conclusions:

  • Routine use of antibiotics, bronchodilators, corticosteroids, steam inhalation, chest physiotherapy, heliox, and antiviral drugs is not recommended for AVB.
  • Clinicians should prioritize supportive care and consider specific evidence-supported interventions like HFNC, CPAP, NIV, nebulized adrenaline, hypertonic saline, and surfactant.