Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Effect of dexamethasone on vascular function in RIF-1 tumors.

P G Braunschweiger, L M Schiffer

    Cancer Research
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Targeting nitric oxide to cancer cells: cytotoxicity studies of glyco-S-nitrosothiols.

    Bioorganic & medicinal chemistry letters·1999
    Same author

    Nitric oxide and neopterin levels and clinical response in stage III melanoma patients receiving concurrent biochemotherapy.

    Melanoma research·1998
    Same author

    Modulation of cisPlatin cytotoxicity by interleukin-1 alpha and resident tumor macrophages.

    Biotherapy (Dordrecht, Netherlands)·1997
    Same author

    Radioresistance in murine solid tumors induced by interleukin-1.

    Radiation research·1996
    Same author

    Synergistic antitumor activity of cisplatin and interleukin 1 in sensitive and resistant solid tumors.

    Cancer research·1993
    Same author

    Dose determination in high dose-rate brachytherapy.

    International journal of radiation oncology, biology, physics·1992

    Dexamethasone significantly impacts RIF-1 tumor vascular function and cell proliferation. This corticosteroid reduces tumor growth by altering capillary permeability, water volumes, and vascular perfusion, influencing tumor recovery.

    Area of Science:

    • Oncology
    • Pharmacology
    • Vascular Biology

    Background:

    • Dexamethasone is a corticosteroid known to affect various physiological processes.
    • RIF-1 tumors possess corticosteroid receptors, making them a relevant model for studying dexamethasone's effects.
    • Understanding dexamethasone's impact on tumor vasculature is crucial for developing effective cancer therapies.

    Purpose of the Study:

    • To investigate the effects of dexamethasone on vascular function and cell proliferation in s.c. RIF-1 tumors.
    • To quantify dexamethasone-induced changes in tumor plasma water, capillary permeability, and extracellular water volumes.
    • To assess alterations in tumor exchangeable erythrocyte volumes and vascular perfusion following dexamethasone treatment.

    Main Methods:

    • Utilized 125I-BSA and 51Cr-EDTA dilution techniques to measure plasma water, capillary permeability, and extracellular water.

    Related Experiment Videos

  • Employed 59Fe and 51Cr labeled erythrocyte techniques to evaluate tumor exchangeable erythrocyte volumes.
  • Conducted 86RbCl distribution studies to assess vascular perfusion in RIF-1 tumors after dexamethasone administration.

    • Main Results:

    • Dexamethasone treatment led to reduced tumor cell proliferation, decreased capillary permeability, and lower interstitial water volumes.
    • Significant increases in plasma volumes and reductions in vascular perfusion were observed post-dexamethasone treatment.
    • Serial studies revealed that enhanced vascular perfusion preceded tumor cell proliferative recovery, with maximal proliferation correlating to increased vascular activity.

    Conclusions:

    • Dexamethasone exerts profound effects on vascular function and water compartmentalization within RIF-1 tumors.
    • The observed changes in vascular parameters suggest a mechanism by which dexamethasone may inhibit tumor growth.
    • These findings highlight the potential of dexamethasone in modulating tumor microenvironment, similar to its effects in edematous normal tissues.