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Related Concept Videos

Amyloid Fibrils03:03

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Related Experiment Video

Updated: Aug 1, 2025

Visualization of Amyloid β Deposits in the Human Brain with Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
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Hepatic Amyloidosis With Multiorgan Involvement.

Robert J Duve1, Tiberiu G Moga2, Kevin Yang1

  • 1Department of Internal Medicine, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY.

ACG Case Reports Journal
|April 24, 2023
PubMed
Summary

Systemic amyloidosis can affect the liver, causing rare but serious complications. This case highlights hepatic involvement in amyloid light chain amyloidosis, emphasizing its diagnostic importance.

Keywords:
AL amyloidacute liver failurehepatic; light-chainight chain amyloidosis

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Area of Science:

  • Medicine
  • Pathology
  • Gastroenterology

Background:

  • Amyloidosis presents diagnostic and therapeutic challenges.
  • Hepatic involvement in amyloidosis, though uncommon, is a critical consideration.
  • Unexplained liver issues warrant investigation for amyloidosis.

Observation:

  • A case of systemic amyloid light chain amyloidosis is presented.
  • The patient exhibited multiorgan involvement, including acute liver injury, cholestasis, nephrotic syndrome, cardiomegaly, and bleeding diathesis.

Findings:

  • Systemic amyloid light chain amyloidosis can lead to severe liver dysfunction.
  • Multisystemic manifestations require a comprehensive diagnostic approach.

Implications:

  • Hepatic amyloidosis should be considered in unexplained liver abnormalities.
  • Recognizing diverse amyloidosis presentations improves patient outcomes.