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Reconstruction of Critical Sized Maxillofacial Defects Using Composite Allogeneic Tissue Engineering: Systematic
Shaqayeq Ramezanzade1, Mahsa Aeinehvand2, Heliya Ziaei2
1Section for Clinical Oral Microbiology, Department of Odontology Cariology and Endodontics, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Biomimetics (Basel, Switzerland)
|April 24, 2023
Summary
Tissue-engineered composite grafts show promise for reconstructing large maxillofacial defects. This evolving science offers potential for vascularized, customizable bone regeneration in reconstructive surgery.
Area of Science:
- Regenerative Medicine
- Biomaterials Science
- Oral and Maxillofacial Surgery
Background:
- Large maxillofacial defects pose significant reconstructive challenges.
- Current reconstructive methods may involve extensive bone harvesting.
- Tissue engineering offers a potential alternative for defect repair.
Purpose of the Study:
- To assess the reliability and efficacy of tissue-engineered composite grafts.
- To evaluate their use in reconstructing large maxillofacial defects.
- To review existing literature on this emerging technology.
Main Methods:
- Systematic literature review of PubMed/Medline, Embase, and Scopus databases.
- Inclusion criteria: patients with large maxillofacial defects treated with composite allogeneic tissue engineering.
- Analysis of 13 eligible studies, encompassing 144 cases.
Main Results:
- Most studies reported successful outcomes in reconstruction.
- The mean patient age was 43.34 years (range 9-89).
- The field of bone tissue engineering for maxillofacial defects is still developing.
Conclusions:
- Tissue-engineered composite grafts demonstrate potential for reconstructing large maxillofacial bony defects.
- Vascularized, customizable bone grafts show promise in short-term follow-ups.
- Further research is needed to establish this as a standard reconstructive approach.
