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Metasurfaces-Driven Hyperspectral Imaging via Multiplexed Plasmonic Resonance Energy Transfer
Inki Kim1,2, Hongyoon Kim3, Seungyeon Han4
1Department of Biophysics, Institute of Quantum Biophysics, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
Advanced Materials (Deerfield Beach, Fla.)
|April 24, 2023
Summary
Researchers developed metasurface-driven plasmonic resonance energy transfer (PRET) hyperspectral imaging for sensitive biomolecule detection. This advanced technique enables multiplexed molecular fingerprinting and real-time imaging in biological samples.
Area of Science:
- Nanotechnology
- Spectroscopy
- Biomedical Imaging
Background:
- Single-molecule biomolecule fingerprinting and dynamic imaging are crucial for life sciences.
- Plasmonic resonance energy transfer (PRET) spectroscopy faces limitations in spectral flexibility and multiplexing capabilities.
Purpose of the Study:
- To report multiplexed metasurfaces-driven PRET hyperspectral imaging for probing biological light-matter interactions.
- To overcome the limitations of conventional PRET spectroscopy for enhanced biomolecular analysis.
Main Methods:
- Engineered pixelated metasurfaces with tunable scattering spectra across the visible range using gap plasmon and grating effects.
- Optical characterization of metasurfaces' dark-field coloration and spectral properties.
- Application of biomolecules (chlorophyll a, chlorophyll b, cytochrome c) on metasurfaces for selective molecular fingerprint imaging.
Main Results:
- Demonstrated engineered metasurfaces with full visible spectrum coloration.
- Achieved selective molecular fingerprint imaging of three distinct biomolecules.
- Showcased the potential for application-specific biomedical metasurfaces.
Conclusions:
- Metasurface-driven PRET hyperspectral imaging offers a novel approach for multiplexed molecular sensing.
- This technique provides a new pathway for real-time molecular imaging in biological systems.
- Enables enhanced understanding of biological light-matter interactions at the molecular level.
