Relation between aortic elasticity parameters and SYNTAX score in postmenopausal diabetic women

Area of Science:

• Cardiology
• Vascular Biology
• Medical Imaging

Background:

• Postmenopausal women have an elevated risk of coronary artery disease (CAD).
• Diabetes Mellitus is a significant risk factor for CAD.
• Aortic stiffening correlates with increased cardiovascular morbidity and mortality.

Purpose of the Study:

• To investigate the relationship between aortic elasticity parameters and CAD severity.
• To assess CAD severity using the SYNTAX score (SS) in diabetic postmenopausal women.
• To determine if echocardiography-derived aortic elasticity can predict SS.

Main Methods:

• Prospective study of 200 diabetic postmenopausal women with CAD undergoing coronary angiography.
• Patients classified into low, intermediate, and high SS groups.
• Echocardiographic measurement of aortic elasticity parameters: aortic stiffness index (ASI), aortic strain (AS), and aortic distensibility (AD).

Main Results:

• Patients with high SS were older and exhibited higher aortic stiffness.
• Aortic distensibility (AD), aortic strain (AS), and aortic stiffness index (ASI) were independent predictors of high SS.
• Significant P-values and cut-off values were identified for AD, AS, and ASI.

Conclusions:

• Simple echocardiography-derived aortic elasticity parameters can predict the severity and complexity of coronary artery disease.
• These parameters may serve as valuable non-invasive tools in diabetic postmenopausal women.
• Findings suggest potential for early risk stratification and management guidance.