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Microvasculature and microstructure alteration in dry-type high myopia.

Shanshan Li¹, Fengshuang Li², Jiao Sun³

¹Department of Ophthalmology, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Journal of Biophotonics

|April 26, 2023

Summary

In high myopia, reduced retinal microvessel density correlates with thinning of the macula, suggesting impaired microstructure due to decreased oxygen and nutrient supply.

Keywords:

high myopia microstructure microvasculature optical coherence tomography angiography (OCTA)

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Evaluation of Capillary and Other Vessel Contribution to Macular Perfusion Density Measured with Optical Coherence Tomography Angiography

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Published on: February 18, 2022

Area of Science:

Ophthalmology
Retinal Imaging
Myopia Research

Background:

Dry-type high myopia involves complex retinal changes.
Understanding these alterations is crucial for managing vision impairment.

Purpose of the Study:

To investigate changes in retinal vasculature and microstructure in dry-type high myopia.
To correlate these changes with disease severity.

Main Methods:

189 eyes with dry-type high myopia were classified into three groups based on retinal lesions (C0, C1, C2).
Optical coherence tomography angiography was used to measure retinal vascular density and thickness.
Statistical analysis included ANOVA and Pearson's correlation.

Main Results:

Significant decrease in microvessel density and macular thickness in the diffuse chorioretinal atrophy group (C2).
Macular vascular density decreased with increased axial length and refractive diopter in the C2 group.
Retinal thickness positively correlated with vascular density in groups C0 and C1.

Conclusions:

Reduced microvessel density in high myopia is linked to impaired retinal microstructure.
This impairment may result from decreased oxygen and nutrient delivery.
Findings highlight the importance of vascular health in myopia progression.