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Motor speech disorders (MSDs) are common in primary progressive aphasia (PPA), affecting nearly half of individuals studied. These disorders present in various forms, including dysarthria and neurogenic stuttering, across all PPA subtypes.

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Area of Science:

  • Neurology
  • Speech-Language Pathology
  • Linguistics

Background:

  • Research on motor speech disorders (MSDs) in primary progressive aphasia (PPA) has predominantly focused on the nonfluent/agrammatic variant (nfvPPA).
  • Existing studies often emphasize apraxia of speech, with limited systematic investigation into other MSDs like dysarthria across diverse PPA subtypes.

Purpose of the Study:

  • To investigate the qualitative and quantitative characteristics of MSDs in a prospective cohort of individuals with PPA, irrespective of their specific subtype.
  • To broaden the understanding of MSDs beyond apraxia of speech and nfvPPA.

Main Methods:

  • 38 participants with a primary progressive aphasia (PPA) diagnosis were included.
  • Speech samples were collected using various modalities and complexity levels.
  • Expert raters performed auditory speech analyses using a novel protocol covering all speech dimensions.

Main Results:

  • Nearly half (47.4%) of participants exhibited some form of MSD.
  • A wide range of individual speech motor profiles were observed, including various dysarthria syndromes, neurogenic stuttering, and mixed forms.
  • MSDs were identified even in patients whose speech and language profiles did not align with nfvPPA.

Conclusions:

  • Motor speech disorders are prevalent in PPA and can manifest as diverse syndromes.
  • Future research should encompass all PPA variants and explore the qualitative aspects of motor speech dysfunction across all speech dimensions.
  • Findings highlight the need for comprehensive assessment of MSDs in PPA.