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Updated: Aug 1, 2025

Catalytic Reactions at Amine-Stabilized and Ligand-Free Platinum Nanoparticles Supported on Titania During Hydrogenation of Alkenes and Aldehydes
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Stimuli-Responsive Double Single-Atom Catalysts for Parallel Catalytic Therapy.

Tushuai Li1,2,3, Yue Gu4, Lisha Yu5

  • 1School of Food Science and Technology, Jiangnan University, Wuxi 214013, China.

Pharmaceutics
|April 28, 2023
PubMed
Summary
This summary is machine-generated.

Novel single-atom nanozymes (SACs) show enhanced nanocatalytic therapy for tumors. These manganese/iron-based SACs effectively generate reactive oxygen species (ROS) and boost antitumor efficacy in preclinical studies.

Keywords:
reactive oxygen speciessingle-atom catalystssynergistic antitumortumor microenvironment

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Catalysis

Background:

  • Nanocatalytic therapy shows promise for tumor targeting but is limited by low catalytic efficiency.
  • Single-atom catalysts (SACs) offer superior catalytic activity compared to traditional nanozymes.
  • The tumor microenvironment (TME) presents unique challenges for effective cancer therapies.

Purpose of the Study:

  • To develop highly efficient single-atom nanozymes (SACs) for enhanced nanocatalytic tumor therapy.
  • To investigate the catalytic mechanisms and antitumor efficacy of novel manganese/iron-based SACs (Mn/Fe PSACs).
  • To explore the synergistic therapeutic effects of Mn/Fe PSACs in vitro and in vivo.

Main Methods:

  • Synthesis of PEGylated manganese/iron-based SACs (Mn/Fe PSACs) coordinated to nitrogen atoms in hollow zeolitic imidazolate frameworks (ZIFs).
  • Evaluation of Mn/Fe PSACs' catalytic activity in converting hydrogen peroxide (H2O2) to hydroxyl radical (•OH) and superoxide ion (•O2−).
  • Assessment of Mn/Fe PSACs' ability to consume glutathione (GSH) and mitigate reactive oxygen species (ROS) depletion.
  • Demonstration of synergistic antitumor efficacy through in vitro and in vivo experiments.

Main Results:

  • Mn/Fe PSACs exhibited high catalytic efficiency through Fenton-like and oxidase-like reactions.
  • The developed SACs effectively generated cytotoxic ROS (•OH and •O2−) within the tumor microenvironment.
  • Mn/Fe PSACs demonstrated significant synergistic antitumor efficacy in both in vitro and in vivo models.
  • The nanozymes showed potential in reducing ROS depletion by consuming GSH.

Conclusions:

  • PEGylated Mn/Fe SACs represent a promising advancement in nanocatalytic therapy with enhanced catalytic activity.
  • These novel SACs offer a synergistic approach to cancer treatment by generating ROS and overcoming TME limitations.
  • The findings provide a strong foundation for developing advanced nanozymes for ROS-related biomedical applications.