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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy
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Dual-Responsive Triple-Synergistic Fe-MOF for Tumor Theranostics.

Zhiwei Chen1, Yaoji Sun1, Jiawei Wang1

  • 1Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Research, School of Electronic Science and Engineering, Xiamen University, Xiamen 361005, People's Republic of China.

ACS Nano
|April 28, 2023
PubMed
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A novel dual-responsive platform (PCN-DOX@PDA) enhances cancer therapy. This intelligent system combines chemotherapy, photothermal, and photodynamic treatments for improved antitumor efficiency and diagnosis.

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Fe-MOFdual-responsivemetal−organic frameworkssynergistic therapytumor diagnosis and treatment

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Oncology

Background:

  • Current cancer therapies often lack efficiency.
  • Intelligent drug delivery systems show promise for precision cancer therapy.
  • Developing multimodal platforms is crucial for enhanced treatment outcomes.

Purpose of the Study:

  • To construct a near-infrared and pH dual-responsive multimodal platform (PCN-DOX@PDA) for cancer diagnosis and treatment.
  • To investigate the synergistic effects of chemotherapy, photothermal therapy (PTT), and photodynamic therapy (PDT).
  • To evaluate the platform's biocompatibility and antitumor efficacy in vivo.

Main Methods:

  • Fabrication of PCN-600 loaded with doxorubicin (DOX) and polydopamine (PDA).
  • Utilizing tetrakis(4-carboxyphenyl)porphyrin (TCPP) for photodynamic therapy (PDT) under 633 nm laser irradiation to generate singlet oxygen (¹O₂).
  • Employing PDA as a photothermal agent for PTT and Fe³⁺ for magnetic resonance imaging (MRI).

Main Results:

  • PCN-DOX@PDA demonstrated intelligent drug release in response to tumor microenvironment acidity and NIR-induced thermal stimulation.
  • The triple synergistic therapy (chemotherapy, PTT, PDT) showed significant antitumor activity.
  • In vivo experiments on 4T1 tumor-bearing mice confirmed excellent biocompatibility and antitumor efficacy.

Conclusions:

  • The PCN-DOX@PDA platform offers a promising strategy for precision cancer therapy.
  • This multimodal approach integrates diagnosis and treatment, enhancing therapeutic outcomes.
  • The developed system has broad prospects for diversified biomedical applications in cancer treatment.