Related Experiment Video
Updated: Jul 31, 2025
09:30
Tissue Characterization after a New Disaggregation Method for Skin Micro-Grafts Generation
Published on: March 4, 2016
21.6K
The Role of Skin Substitutes in Dermatologic Surgery: A Practical Review
Journal of Drugs in Dermatology : JDD
|May 3, 2023
Summary
Dermatologists can now choose from various skin substitutes (SS) for wound care. This review guides selection by detailing the efficacy, risks, and costs of different SS types to improve wound healing.
Area of Science:
- Dermatology
- Wound Care
- Regenerative Medicine
Background:
- The market for skin substitutes (SS) has expanded significantly.
- Choosing the appropriate SS for wound management poses a challenge for dermatologists.
Purpose of the Study:
- To provide a practical review of SS used in dermatologic surgery.
- To aid clinicians in selecting SS by detailing efficacy, risk, availability, shelf-life, and cost.
Main Methods:
- Literature search of PubMed and company websites.
- Manual review of reference sections and expert consultation.
Main Results:
- Skin substitutes are categorized into seven types: amnion, cultured epithelial autograft, acellular allograft, cellular allografts, xenografts, composites, and synthetics.
- Each category presents distinct advantages and disadvantages.
Conclusions:
- Understanding SS characteristics and efficacies can enhance wound care and healing times.
- Further research is required to compare the healing benefits and efficacy of various SS.
Related Concept Videos
01:19Clinical Applications of Epidermal Stem Cells
2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
01:22Burn Injuries
2.6K
Burn injuries occur when the skin and underlying tissues are damaged due to exposure to heat, electricity, chemicals, radiation, or friction. They can vary in severity, from minor superficial burns to severe deep burns that can be life-threatening.
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
2.6K
01:12Renewal of Skin Epidermal Stem Cells
2.6K
The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
2.6K