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Lymphoma Masquerading as Lung Cancer.
Hong Zhi Alvin Ng1, Lenith Tai Jit Cheng, Pei Ing Ngam
1From the National University Hospital Singapore.
Clinical Nuclear Medicine
|May 3, 2023
Summary
This study details an unusual B-cell lymphoma case presenting as a tumor thrombus in the pulmonary vein and left atrium, mimicking lung cancer metastasis. This highlights rare lymphoma manifestations and diagnostic challenges.
Area of Science:
- Oncology
- Hematology
- Radiology
Background:
- Lymphoma commonly presents as lymphadenopathy, often with solid organ involvement.
- Lymphomatous masses typically encase anatomical structures rather than invading them.
- Tumor thrombus formation is a rare but documented presentation of lymphoma in organs like the liver and kidneys.
Observation:
- This report describes a unique case of B-cell lymphoma.
- The lymphoma exhibited imaging findings that mimicked metastatic lung cancer.
- Specifically, the tumor formed a thrombus within the pulmonary vein and left atrium.
Findings:
- The B-cell lymphoma presented as a tumor thrombus in the pulmonary vein and left atrium.
- These findings were initially suggestive of metastatic lung cancer.
- This represents an atypical presentation of lymphoma.
Implications:
- This case underscores the importance of considering lymphoma in the differential diagnosis of unexplained tumor thrombus formation.
- Radiologists and oncologists should be aware of rare lymphoma presentations that can mimic other malignancies.
- Accurate diagnosis is crucial for appropriate treatment and patient management.

