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Updated: Jul 31, 2025

Visualizing Axonal Growth Cone Collapse and Early Amyloid β Effects in Cultured Mouse Neurons
Published on: October 30, 2018
[Cerebral amyloid angiopathy-related cognitive decline: small vessels, big problems]
Lukas Sveikata1, Patrick Stancu1, Nicolae Sanda1
1Service de neurologie, Département de neurosciences cliniques, Hôpitaux universitaires de Genève et Faculté de médecine, Université de Genève, 1211 Genève 4.
Abstract:
Cerebral amyloid angiopathy (CAA) is a common and well-defined small vessel disease characterized by the deposition of amyloid β in the vascular wall. CAA causes devastating outcomes related to intracerebral hemorrhage and cognitive decline in older adults. The shared pathogenic pathway between CAA and Alzheimer's disease, co-occuring frequently in the same subject, has important implications for cognitive outcomes and novel anti-amyloid-β immunotherapies. In this review, we present the epidemiology, pathophysiology, current diagnostic criteria of CAA, and future developments in the field.
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