[Activation analysis with reactor and 14 MeV neutrons in an experimental study of oxoplatinum]

The authors described a procedure of the instrumental neutron activation analysis of biomedical material on reactor and 14 MeV neutrons for determination of the platinum, silicon, chlorine, phosphorus, sodium and zinc content using the anticompton system of detection together with a programmed analyser and an automatic sample changer. The procedure was tested on rat small intestinal samples within the interval of 10 min-30 days after a single i. v. administration of oxoplatinum (15 mg per 1 kg of the animal body mass). Platinum redistribution with relative concentration maximum on the 15th day was noted. Changes in the phosphorus, chlorine, sodium and silicon content within the interval of 3-30 days were suggestive of a possible toxic effect of oxoplatinum metabolites during this period. In a clinical application of oxoplatinum one should take into account a possible toxic effect of metabolites in a long-term period after repeated administration of the agent.