The novel HLA-A*11:443 allele characterised by two different sequencing-based typing techniques

Area of Science:

• Immunogenetics
• Molecular biology

Background:

• The human leukocyte antigen (HLA) system plays a critical role in immune response.
• Polymorphisms in HLA genes contribute to diverse immune profiles and disease susceptibility.

Purpose of the Study:

• To report the discovery and characterization of a novel HLA allele.

Main Methods:

• Sequence analysis of the HLA-A gene.
• Comparison with existing HLA allele databases.

Main Results:

• A novel HLA allele, designated HLA-A*11:443, was identified.
• This allele differs from the common HLA-A*11:01:01:01 by a single non-synonymous nucleotide substitution located in exon 2.

Conclusions:

• The identification of HLA-A*11:443 expands the known HLA allele repertoire.
• This finding contributes to a more comprehensive understanding of HLA polymorphism.