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Updated: Jul 31, 2025

A Detailed Protocol for Characterizing the Murine C1498 Cell Line and its Associated Leukemia Mouse Model
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Modern Classification and Management of Pediatric B-cell Leukemia and Lymphoma

Alexandra E Kovach1, Gordana Raca2

  • 1Division of Laboratory Medicine, Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA; Clinical Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90027, USA.

Surgical Pathology Clinics
|May 6, 2023
PubMed

Insights

Pediatric hematopathology features unique leukemias and lymphomas. This review covers new lymphoblastic leukemia subtypes and key concepts in pediatric lymphoma diagnosis since 2017.

Area of Science:

  • Hematopathology
  • Pediatric Oncology
  • Lymphoma Research

Background:

  • Pediatric hematopathology shares similarities with adult forms but includes unique conditions.
  • Certain leukemias, lymphomas, and reactive bone marrow/lymph node disorders are specific to children.
  • This article focuses on lymphomas within the pediatric hematopathology context.

Purpose of the Study:

  • To detail novel subtypes of lymphoblastic leukemia in children described since the 2017 WHO classification.
  • To discuss unique concepts in pediatric hematopathology, including nomenclature and surgical margin evaluation for lymphomas.

Main Methods:

  • Review of recent literature and classifications (e.g., 2017 WHO).
  • Analysis of novel lymphoblastic leukemia subtypes primarily affecting children.
  • Discussion of diagnostic concepts and evaluation techniques in pediatric lymphomas.

Main Results:

  • Identification and description of newly classified lymphoblastic leukemia subtypes in pediatric patients.
  • Elucidation of evolving nomenclature and diagnostic criteria in pediatric hematopathology.
  • Guidance on evaluating surgical margins for specific pediatric lymphomas.

Conclusions:

  • Pediatric hematopathology encompasses distinct lymphoblastic leukemia subtypes requiring specialized classification.
  • Updated nomenclature and diagnostic approaches are crucial for accurate pediatric lymphoma management.
  • Understanding unique pediatric hematopathology concepts improves diagnostic accuracy and patient care.

Keywords:
Anterior mediastinal massB-lymphoblastic leukemiaHematogone hyperplasiaLymphadenitisPediatric leukemiaPediatric lymphomaWHO classification

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