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UNDIFFERENTIATED PLEOMORPHIC SARCOMA: PROGNOSTIC FACTORS IN 42 EXTREMITY CASES
Carlos Henrique Maçaneiro1, André Mathias Baptista1, Olavo Pires DE Camargo1
1Universidade de Sao Paulo, Faculdade de Medicina, Hospital das Clínicas, Instituto de Ortopedia e Traumatologia, Sao Paulo, SP, Brazil.
Acta Ortopedica Brasileira
|May 8, 2023
Summary
Metastatic lesions and advanced stage IV (American Joint Committee on Cancer) are key indicators of poor prognosis for soft tissue undifferentiated pleomorphic sarcoma (UPS) of the extremities, significantly reducing survival rates.
Area of Science:
- Oncology
- Surgical Pathology
- Sarcoma Research
Background:
- Soft tissue undifferentiated pleomorphic sarcoma (UPS) is a rare soft tissue sarcoma (STS), accounting for 5% of STS cases.
- Understanding prognostic factors for UPS in extremities is crucial for patient management and treatment strategies.
Purpose of the Study:
- To identify and evaluate prognostic factors associated with mortality, local recurrence, and survival rates in patients with UPS of the extremities.
- To assess the impact of tumor characteristics and disease stage on patient outcomes.
Main Methods:
- Retrospective analysis of 42 patients with extremity UPS treated surgically at a single institution.
- Statistical analysis included logistic regression for significant variables and Kaplan-Meier plots with Log-Rank tests for survival analysis.
Main Results:
- Tumor size greater than 15 cm (T4) and American Joint Committee on Cancer (AJCC) stage IV were significant predictors of survival (p=0.01 and p<0.001, respectively).
- Presence of metastatic lesions and AJCC stage IV were strongly associated with reduced patient survival (mean survival 17.8 months).
- The overall mean survival for the cohort was 25.9 months.
Conclusions:
- Metastatic lesions and AJCC stage IV are the primary indicators of poor prognosis in patients with UPS of the extremities.
- These factors significantly correlate with increased mortality and reduced survival rates, highlighting the need for early detection and aggressive management.
