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Microneedle arrays integrated with microfluidic systems: Emerging applications and fluid flow modeling
Abdollah Ahmadpour1, Pelin Kubra Isgor2, Berk Ural1
1Department of Mechanical Engineering, College of Engineering, Koç University, Türkiye.
Biomicrofluidics
|May 8, 2023
Summary
Microneedle arrays combined with microfluidics create advanced biomedical devices. This review covers their designs, applications in drug delivery and biosensing, and modeling approaches.
Area of Science:
- Biomedical Engineering
- Microfluidics
- Nanotechnology
Background:
- Microneedle arrays are micro/nano-scale needle patches.
- They are versatile technologies for biomedical applications.
- Integration with microfluidic systems enhances device capabilities.
Purpose of the Study:
- To review microneedle array designs and applications.
- To discuss modeling approaches for fluid flow and mass transfer in microneedles.
- To highlight current challenges in microneedle technology.
Main Methods:
- Literature review of microneedle array designs and applications.
- Analysis of modeling techniques for fluid dynamics and mass transfer.
- Identification and discussion of challenges in the field.
Main Results:
- Microneedle-microfluidic devices show promise in drug delivery, wound healing, biosensing, and body fluid sampling.
- Various modeling approaches exist for optimizing microneedle performance.
- Key challenges include scalability, manufacturing, and in vivo performance.
Conclusions:
- Microneedle-microfluidic systems offer significant potential for advanced biomedical applications.
- Further research and development are needed to overcome existing challenges.
- Optimized modeling is crucial for the design and application of these devices.
