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Updated: Jul 31, 2025

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Three-component regioselective carboamidation of 1,3-enynes via rhodium(III)-catalyzed C-H activation
Lingheng Kong1,2, Xi Han1, Panjie Hu1
1School of Chemistry and Chemical Engineering, Shaanxi Normal University (SNNU), Xi'an, 710062, China. lixw@snnu.edu.cn.
Abstract:
Rhodium-catalyzed regio- and stereoselective three-component carboamidation of 1,3-enynes has been realized using indoles and dioxazolones as the functionalizing reagents. A wide range of multi-substituted skipped 1,4-dienes have been constructed in good yields and excellent stereoselectivity. The stereoselectivity is under substrate control. 1,3-Enynes bearing a relatively bulky alkyne terminus reacted with Z-selectivity. In contrast, a sterically less hindered alkyne terminus tends to predominantly give the E-configured skipped diene.
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