Exploring the genetic correlation of cardiovascular diseases and mood disorders in the UK Biobank

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Chi-Jen Chen1, Wan-Yu Liao1, Amrita Chattopadhyay2

  • 1Institute of Epidemiology and Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan University, Taipei, Taiwan.

Epidemiology and Psychiatric Sciences
|May 10, 2023
PubMed

Insights

Cardiovascular diseases (CVDs) and major depressive disorder (MDD) share significant genetic links, suggesting a common genetic basis. This genetic overlap highlights potential shared risk factors between these conditions.

Area of Science:

  • Genetics
  • Psychiatry
  • Cardiology

Background:

  • Cardiovascular diseases (CVDs) are a leading global cause of death.
  • Individuals with mood disorders exhibit higher CVD incidence and mortality.
  • Major depressive disorder (MDD) is a common comorbidity in CVD patients.

Purpose of the Study:

  • To investigate the genetic correlation between CVDs and mood disorders.
  • To understand the genetic factors contributing to the comorbidity of CVDs and mood disorders.
  • Utilize UK Biobank data for comprehensive genetic association studies.

Main Methods:

  • Analysis of UK Biobank data from 117,925 participants.
  • Inclusion of 6,128,294 genetic variants for analysis.
  • Focus on two CVD phenotypes, two mood disorders, and 12 cardiometabolic traits.

Main Results:

  • Significant positive genetic correlation found between CVDs and overall mood disorders, including MDD.
  • Substantial genetic overlap identified between CVDs and MDD.
  • No significant genetic correlation observed between CVDs and bipolar disorder.

Conclusions:

  • CVDs and mood disorders share significant genetic liability.
  • Findings are particularly relevant for individuals of European ancestry.
  • Genetic insights may inform future prevention and treatment strategies.
Abstract

Keywords:
bipolar disorderchronic conditionsdepressionlinkage disequilibriumstatistics

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