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Updated: Jul 30, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Novel agents and evolving strategies in myelofibrotive neoplasm: an update from 2022 ASH annual conference

Andrew Wang1, James Liu2, Jeffrey J Pu3

  • 1Pennsylvania State University, University Park, PA, 16802, USA.

Journal of Hematology & Oncology
|May 12, 2023
PubMed

Insights

Myelofibrosis treatments targeting JAK signaling improve symptoms but have limitations. New targeted therapies are emerging to address unmet needs in this incurable blood cancer.

Area of Science:

  • Hematology
  • Oncology
  • Molecular Biology

Background:

  • Myelofibrosis (MF) is a clonal hematopoietic stem cell disorder.
  • Overactive Janus kinase (JAK) signaling, particularly JAK2V617F mutation, drives MF pathogenesis.
  • Current JAK inhibitors (JAKi) offer clinical benefits but have limitations like cytopenia and disease recurrence.
Keywords:
Clinical researchMyelofibrotive neoplasmTargeted therapy

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