Related Experiment Video

Updated: Jul 30, 2025

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption
12:02

Human Primary Trophoblast Cell Culture Model to Study the Protective Effects of Melatonin Against Hypoxia/reoxygenation-induced Disruption

Published on: July 30, 2016

16.0K

Melatonin and Kidney Health: From Fetal Stage to Later Life

Kuo-Shu Tang1, Chun-Yi Ho1,2, Chien-Ning Hsu3,4

  • 1Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 833, Taiwan.

International Journal of Molecular Sciences
|May 13, 2023
PubMed

Insights

Melatonin, a natural hormone, shows promise in preventing kidney disease, especially in early life. This review explores its role in kidney development and therapeutic potential for chronic kidney disease (CKD).

Area of Science:

  • Endocrinology
  • Nephrology
  • Developmental Biology

Background:

  • Melatonin is an endogenous hormone with diverse functions.
  • Chronic kidney disease (CKD) prevalence is increasing globally.
  • Early life factors significantly influence adult kidney health.

Purpose of the Study:

  • To review melatonin's impact on kidney development.
  • To assess clinical applications of melatonin in early life.
  • To examine animal models of melatonin's preventive effects on offspring kidney disease.
  • To summarize therapeutic considerations for melatonin supplementation.

Main Methods:

  • Literature review of recent studies.
  • Analysis of research on melatonin and kidney development.
  • Evaluation of clinical trials and animal models.

Main Results:

  • Emerging evidence highlights melatonin's critical role in kidney health and disease.
  • Melatonin may offer preventive strategies against kidney damage originating in early life.
  • Animal studies demonstrate melatonin's protective effects on offspring kidney health.

Conclusions:

  • Melatonin holds significant potential for preventing and treating kidney diseases, particularly when initiated early in life.
  • Further research into therapeutic applications of melatonin supplementation is warranted for improving global kidney health.
Keywords:
antioxidantcircadian rhythmdevelopmental origin of health and disease (DOHaD)developmental programmingkidney diseasemelatoninpregnancy

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