Related Experiment Video
Updated: Jul 30, 2025
08:48
Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
Published on: April 21, 2022
2.5K
Arachidonic Acid Pathways and Male Fertility: A Systematic Review
Malvina Hoxha1, Arcangelo Barbonetti2, Bruno Zappacosta1
1Department for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, 1000 Tirana, Albania.
International Journal of Molecular Sciences
|May 13, 2023
Summary
Arachidonic acid (AA) pathways influence male fertility. Targeting these pathways, particularly prostaglandin E (PGE), shows promise for treating infertility by improving sperm function and semen parameters.
Area of Science:
- Reproductive biology
- Biochemistry
- Human physiology
Background:
- Arachidonic acid (AA) is a polyunsaturated fatty acid crucial for male reproductive functions.
- Human seminal fluid contains various prostaglandins (PGs), including PGE and PGF2α, which play roles in fertility.
- Dysregulation of the AA pathway is implicated in male infertility.
Conclusions:
- Targeting the arachidonic acid (AA) pathway presents a potential therapeutic strategy for male infertility.
- PGE agonists may offer a novel approach to improving male fertility.
- Further research into AA pathway modulation could lead to effective treatments for infertility.
Related Concept Videos
01:23Infertility in Males
303
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
303
01:41Spermatogenesis
102.7K
Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
102.7K
01:22Sperm Structure and Semen Composition
3.2K
During ejaculation, males release around 2-5 milliliters of semen, which is a complex mixture of mature sperm and various fluids produced by accessory glands. The mature sperm cells measure approximately 60 micrometers in length and consist of a head, neck, midpiece, and tail. The head is flattened and tapered, measuring about 4 to 5 micrometers in length. It contains a nucleus with condensed chromosomes and an acrosome, a cap-like structure filled with enzymes essential for penetrating the...
3.2K
01:25Accessory Ducts of the Male Reproductive System
1.4K
The male reproductive system is a complex network of organs and tissues that work together to produce and transport sperm. The epididymis, vasa deferens, ejaculatory ducts, and urethra are the accessory ducts involved in sperm maturation and transportation. These ducts play a critical role in the production and transportation of sperm from the testes to the urethra, where it is then released during ejaculation.
The epididymis is a small, comma-shaped organ located at the back of each testicle....
The epididymis is a small, comma-shaped organ located at the back of each testicle....
1.4K
01:28Infertility in Females
357
Female infertility is defined as the inability to conceive after a year of regular, unprotected intercourse and affects about 10–15% of couples worldwide. The primary cause of female infertility is ovulatory disorders, which hinder the release of eggs. These disorders can be classified as hypothalamic amenorrhea, polycystic ovarian syndrome (PCOS), premature ovarian failure, and hyperprolactinemic anovulation disorders.
Endometriosis, a condition characterized by abnormal growth of...
Endometriosis, a condition characterized by abnormal growth of...
357
01:20Disorders of the Male Reproductive System
485
Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra....
485