Natural Compounds Targeting SIRT1 and Beyond: Promising Nutraceutical Strategies Against Atherosclerosis
1Department for Chemical-Toxicological and Pharmacological Evaluation of Drugs, Faculty of Pharmacy, Catholic University Our Lady of Good Counsel, Rruga Dritan Hoxha, 1000 Tirana, Albania.
Nutrients
|November 13, 2025
Summary
Natural compounds like resveratrol activate Sirtuin 1 (SIRT1), offering potential to combat atherosclerosis. This review explores their vascular benefits and therapeutic promise for cardiovascular diseases.
Area of Science:
- Cardiovascular Science
- Molecular Biology
- Nutraceuticals
Background:
- Atherosclerosis is a major global health concern requiring new treatments.
- Sirtuin 1 (SIRT1) regulates vascular health, impacting key pathways in cardiovascular disease.
- Natural SIRT1 activators show promise for preventing and treating cardiovascular conditions.
Purpose of the Study:
- To review natural activators of Sirtuin 1 (SIRT1) relevant to vascular impairment.
- To investigate the therapeutic potential of these compounds in atherosclerosis.
Main Methods:
- Literature search of PubMed and Scopus databases.
- Inclusion of studies from January 2000 to June 2025.
- Focus on natural SIRT1 activators and their role in atherosclerosis.
Main Results:
- Resveratrol, quercetin, naringenin, and hydroxytyrosol demonstrate significant SIRT1 activation.
- These compounds modulate molecular pathways crucial to atherosclerotic disease.
- Evidence ranges from preclinical to clinical studies, with limited clinical trial data on hard outcomes.
Conclusions:
- Natural SIRT1 activators hold potential for managing atherosclerosis.
- Understanding their molecular mechanisms is key for clinical application.
- Nutraceutical-based strategies targeting SIRT1 may offer novel approaches for cardiovascular disease.
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