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Infliximab Inhibits Colitis Associated Cancer in Model Mice by Downregulating Genes Associated with Mast Cells and

Dan-Yang Wang1, Shinobu Ohnuma1, Hideyuki Suzuki1

  • 1Department of Surgery, Tohoku University Graduate School of Medicine, Sendai 980-8574, Japan.

Current Issues in Molecular Biology
|May 15, 2023
PubMed
Summary

Anti-tumor necrosis factor-alpha (TNF-α) antibodies, used for inflammatory bowel diseases (IBD), were investigated for their role in colon cancer. Infliximab attenuated colitis-associated cancer development in mice, implicating mast cells in the process.

Keywords:
Crohn’s diseaseTNF-αanti TNF-α antibodyazoxymethane (AOM)/dextran sodium sulfate (DSS) mousecolitis-associated cancerinflammatory bowel diseaseinfliximabmast cellulcerative colitis

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