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Updated: Jul 30, 2025
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Expression of Exogenous Cytokine in Patient-derived Xenografts via Injection with a Cytokine-transduced Stromal Cell Line
Published on: May 10, 2017
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[Post-transplant lymphoproliferative disorders]
Sabrina Forsell1, Noémie Lang1,2
1Faculté de médecine, Université de Genève, 1211 Genève 4.
Revue Medicale Suisse
|May 17, 2023
Summary
Post-transplant lymphoproliferative disorders (PTLD) are common in transplant recipients. Early detection and risk-adapted management of these Epstein-Barr virus-related B-cell cancers are crucial for improving patient outcomes.
Area of Science:
- Immunology
- Oncology
- Transplantation Medicine
Background:
- Post-transplant lymphoproliferative disorders (PTLD) are a significant complication following organ transplantation.
- PTLD incidence varies based on recipient factors and transplanted organ type.
- The pathogenesis involves a T-cell immune surveillance imbalance and Epstein-Barr virus (EBV) reactivation in B lymphocytes.
Conclusions:
- PTLD requires careful surveillance and tailored treatment approaches.
- Understanding PTLD pathogenesis is key to managing transplant recipients.
- Early diagnosis significantly enhances the prognosis for transplant patients with PTLD.
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