Novel Agents in Waldenström Macroglobulinemia

Owing to the indolent nature of Waldenström macroglobulinemia, most patients experience a prolonged life expectancy, although many lines of therapy will likely be required to maintain disease control. Despite the currently available therapies, most patients will develop intolerance or resistance to multiple treatments. Therefore, new therapeutic options are being developed with a focus on targeted agents, such as novel Bruton tyrosine kinase (BTK) inhibitors and BTK degraders, as well as C-X-C chemokine receptor type 4, mucosa-associated lymphoid tissue translocation protein 1, and interleukin-1 receptor-associated kinase 4.