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Responses of pyramidal cell somata and apical dendrites in mouse visual cortex over multiple days
Colleen J Gillon1,2,3, Jérôme A Lecoq4, Jason E Pina5,6
1Department of Cell & Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Scientific Data
|May 17, 2023
Summary
This study presents a new dataset for comparing apical dendrite and cell body responses in visual cortical pyramidal neurons over multiple days. This data enables research into the distinct roles of neuronal compartments in learning and plasticity.
Area of Science:
- Neuroscience
- Computational Neuroscience
- Systems Neuroscience
Background:
- Apical dendrites of pyramidal neurons receive top-down signals, while cell bodies receive bottom-up inputs.
- Computational neuroscience theories suggest unique roles for apical dendrites in neural learning.
- Limited data exists comparing apical dendrite and cell body responses over time due to data collection challenges.
Purpose of the Study:
- To present a novel dataset for comparing apical dendrite and cell body activity in visual cortical pyramidal neurons.
- To enable investigation into the differential processing and plasticity between neuronal compartments.
- To address the need for longitudinal data on neuronal responses.
Main Methods:
- High-quality two-photon calcium imaging was used.
- Data was collected from apical dendrites and cell bodies of visual cortical pyramidal neurons in awake, behaving mice.
- Recordings were performed over multiple days with visual stimuli presentation.
Main Results:
- The dataset includes longitudinally tracked cell bodies and dendrite segments.
- It allows for the analysis of changes in neuronal responses over multiple days.
- High-quality imaging data captures activity in distinct neuronal compartments.
Conclusions:
- The dataset facilitates exploration of differences between apical and somatic processing.
- It supports research into the role of apical dendrites in learning and plasticity.
- This resource aids in understanding neuronal computation in sensory cortices.
