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Subretinal Pseudocysts: A Comprehensive Analysis of this Novel OCT Finding
Matteo Menean1,2,3, Riccardo Sacconi1,2,3, Stela Vujosevic4,5
1School of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
Ophthalmology and Therapy
|May 17, 2023
Summary
Subretinal pseudocysts, identified via optical coherence tomography (OCT), are transient findings often associated with retinal diseases. While usually resolving, they can indicate photoreceptor loss and retinal pigment epithelium changes.
Area of Science:
- Ophthalmology
- Medical Imaging
- Retinal Diseases
Background:
- Optical coherence tomography (OCT) is crucial for assessing retinal diseases.
- Subretinal pseudocysts are rare OCT findings characterized by hyperreflective borders.
- Previous reports on subretinal pseudocysts are limited.
Purpose of the Study:
- To characterize novel subretinal pseudocyst findings on OCT.
- To investigate the clinical outcome and associated retinal conditions.
- To explore the significance of subretinal pseudocysts in retinal disease prognosis.
Main Methods:
- Retrospective analysis of patients with subretinal cystoid spaces on OCT scans.
- Inclusion of patients regardless of concurrent retinal diseases.
- Baseline and follow-up examinations using OCT and OCT-angiography.
Main Results:
- Twenty-eight eyes with 31 subretinal pseudocysts were analyzed.
- Commonly associated with neovascular age-related macular degeneration (AMD), central serous chorioretinopathy, and diabetic retinopathy.
- Pseudocysts were positively associated with subretinal fluid height and central macular thickness.
- Most pseudocysts resolved on follow-up, but some eyes developed retinal atrophy.
Conclusions:
- Subretinal pseudocysts are likely transient OCT findings associated with subretinal fluid.
- These pseudocysts can be linked to photoreceptor loss and compromised retinal pigment epithelium.
- Further research is needed to fully understand their long-term implications.
