Related Experiment Video
Updated: Jul 30, 2025
Opsono-Adherence Assay to Evaluate Functional Antibodies in Vaccine Development Against Bacillus anthracis and Other Encapsulated Pathogens
Published on: May 19, 2020
Low seroprotection against diphtheria and tetanus in Lao adolescents
Sonephet Vantava1, Lisa Hefele2, Siriphone Virachith3
1Lao Tropical and Public Health Institute, Ministry of Health, Vientiane, Lao People's Democratic Republic.
Objectives:
There is currently no booster diphtheria or tetanus vaccine for Lao children before adolescence, despite international recommendations. We investigated seroprotection against diphtheria and tetanus among Lao adolescents.
Methods:
Seven hundred seventy-nine serum samples were tested for anti-diphtheria and anti-tetanus antibodies.
Results:
Overall, 25.8% of the adolescents had antibody titers corresponding to protection against diphtheria and 30.9% to sufficient immunity against tetanus. Female participants >16 years were more likely to be protected against diphtheria (p < 0.001) and tetanus (p < 0.029).
Conclusion:
Low protection against diphtheria and tetanus, possibly due to low vaccination coverage or antibody waning, suggests booster doses are warranted before adolescence.
More Related Videos
06:22Standardization of Transfer across Labs between Flow Cytometers for Detection of Lymphocytes in Japanese Encephalitis Vaccinated Children
Published on: February 10, 2023
09:25Detection and Enrichment of Rare Antigen-specific B Cells for Analysis of Phenotype and Function
Published on: February 16, 2017
