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Stem Cell Therapy for Tissue Regeneration01:21

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Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
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Stem Cell-Based Tissue Engineering for Cleft Defects: Systematic Review and Meta-Analysis.

Diandra S Natsir Kalla1,2, Salem A Alkaabi1,3, Faqi N Hendra1,4

  • 1Department of Oral and Maxillofacial Surgery/Oral Pathology, Amsterdam University Medical Centers and Academic Centre for Dentistry Amsterdam (ACTA), Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, The Netherlands.

The Cleft Palate-Craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
|May 19, 2023
PubMed
Summary
This summary is machine-generated.

Stem cell-based tissue engineering shows potential for alveolar cleft and cleft palate repair in preclinical models. While not statistically significant, adding cells to scaffolds improved bone formation, guiding future clinical trials.

Keywords:
alveolar cleftanimal studycleft palatestem cellsystematic review

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Area of Science:

  • Regenerative Medicine
  • Biomaterials Science
  • Maxillofacial Surgery

Background:

  • Alveolar cleft (AC) and cleft palate (CP) defects pose significant reconstructive challenges.
  • Current treatments often involve autografts with limitations.
  • Stem cell-based tissue engineering offers a promising alternative for bone regeneration.

Purpose of the Study:

  • To systematically review and meta-analyze the efficacy of stem cell-based tissue engineering for AC and CP reconstruction in animal models.
  • To evaluate new bone formation (NBF) and bone mineral density (BMD) as outcome parameters.
  • To assess the potential of regenerative grafts compared to traditional methods.

Main Methods:

  • Systematic review and meta-analysis of preclinical studies.
  • Searched PubMed, Embase, and Cochrane databases for studies on AC and CP reconstruction using stem cell-based tissue engineering.
  • Included 13 large and 12 small animal studies; quality assessed using SYRCLE.
  • Outcome parameters: NBF and BMD.

Main Results:

  • Meta-analyses for AC showed non-significant benefits for scaffold + cells over scaffold-only and empty controls.
  • Studies in dogs demonstrated regenerative grafts were comparable or superior to autografts for bone formation.
  • Meta-analysis for CP was not feasible due to limited data.

Conclusions:

  • The addition of osteogenic cells to biomaterials enhances AC and CP reconstructions.
  • Preclinical findings suggest potential for stem cell-based therapies in clinical applications.
  • Further research is needed to optimize treatment efficacy and guide clinical trials for bone tissue engineering.