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Microneedle system with light trigger for precise and programmable penetration
Weijiang Yu1, Jieze Shen1, Chong Ji1
1MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. yx_wang@zju.edu.cn.
Materials Horizons
|May 22, 2023
Summary
This study introduces a new microneedle (MN) insertion method using shape memory polymers triggered by near-infrared light. This technique offers precise force control for safer and more effective biomedical applications.
Area of Science:
- Biomedical Engineering
- Materials Science
- Polymer Science
Background:
- Microneedle (MN) systems offer broad biomedical potential but face challenges with controlled insertion.
- Current MN insertion methods lack precision, limiting their application scope.
Purpose of the Study:
- To develop a novel strategy for precisely controlled microneedle insertion.
- To enable remote, spatiotemporal control over MN delivery for biomedical applications.
Main Methods:
- Utilized near-infrared light-triggered shape memory polymers (SMPs) for MN insertion.
- Implemented tunable light intensity for precise force control (15 mN).
- Predetermined SMP pre-stretch strain to control penetration depth.
Main Results:
- Demonstrated precise MN insertion into the rabbit cornea stromal layer.
- Achieved programmable MN insertion for multistage and patterned payload delivery.
- Validated remote, precise, and spatiotemporal control of MN insertion.
Conclusions:
- The novel SMP-based strategy enables highly controlled MN insertion.
- This approach enhances safety and precision for MN-based therapies.
- The technology holds promise for advancing microneedle applications in drug delivery and beyond.
