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Updated: Jul 29, 2025

Microinjectrode System for Combined Drug Infusion and Electrophysiology
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Microneedle system with light trigger for precise and programmable penetration.

Weijiang Yu1, Jieze Shen1, Chong Ji1

  • 1MOE Key Laboratory of Macromolecule Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China. yx_wang@zju.edu.cn.

Materials Horizons
|May 22, 2023
PubMed
Summary
This summary is machine-generated.

This study introduces a new microneedle (MN) insertion method using shape memory polymers triggered by near-infrared light. This technique offers precise force control for safer and more effective biomedical applications.

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Polymer Science

Background:

  • Microneedle (MN) systems offer broad biomedical potential but face challenges with controlled insertion.
  • Current MN insertion methods lack precision, limiting their application scope.

Purpose of the Study:

  • To develop a novel strategy for precisely controlled microneedle insertion.
  • To enable remote, spatiotemporal control over MN delivery for biomedical applications.

Main Methods:

  • Utilized near-infrared light-triggered shape memory polymers (SMPs) for MN insertion.
  • Implemented tunable light intensity for precise force control (15 mN).
  • Predetermined SMP pre-stretch strain to control penetration depth.

Main Results:

  • Demonstrated precise MN insertion into the rabbit cornea stromal layer.
  • Achieved programmable MN insertion for multistage and patterned payload delivery.
  • Validated remote, precise, and spatiotemporal control of MN insertion.

Conclusions:

  • The novel SMP-based strategy enables highly controlled MN insertion.
  • This approach enhances safety and precision for MN-based therapies.
  • The technology holds promise for advancing microneedle applications in drug delivery and beyond.