CTHRC1, a novel gene with multiple functions in physiology, disease and solid tumors (Review)

Area of Science:

• Molecular Biology
• Genetics
• Oncology

Background:

• Collagen triple helix repeat containing 1 (CTHRC1) is a highly conserved gene identified in 2005.
• CTHRC1 plays crucial roles in normal physiological processes like metabolism, arterial remodeling, bone formation, and peripheral nervous system myelination.
• Aberrant CTHRC1 expression is implicated in the carcinogenesis of multiple human organs, including breast, colon, pancreas, lung, stomach, and liver.

Purpose of the Study:

• To review and synthesize current knowledge on the regulation of CTHRC1 gene expression.
• To explore signaling pathways associated with CTHRC1.
• To propose a hypothesis regarding the functional mechanism of CTHRC1.

Main Methods:

• Literature review of existing studies on CTHRC1.
• Analysis of reported findings on CTHRC1 expression and its regulatory mechanisms.
• Synthesis of data on CTHRC1's role in physiological and pathological processes.

Main Results:

• CTHRC1 is expressed in normal tissues and involved in key biological functions.
• Dysregulation of CTHRC1 is a common feature in several types of cancer.
• Specific regulatory mechanisms and signaling pathways influencing CTHRC1 are documented.

Conclusions:

• CTHRC1 is a significant gene with established roles in normal physiology and disease.
• Understanding CTHRC1 regulation and pathways is critical for cancer research.
• Further investigation into CTHRC1's functional mechanisms may reveal therapeutic targets.