Related Experiment Video
Updated: Jul 29, 2025
10:31
Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
233
Diabetic nephropathy with marked extra-capillary cell proliferation: a case report
Madoka Morimoto1, Tomoko Namba-Hamano2, Shoki Notsu3
1Department of Nephrology, Sakai City Medical Center, 1-1-1 Ebaraji-Cho, Nishi-Ku, Sakai City, Osaka, Japan. m_i_morimoto@sakai-hospital.jp.
BMC Nephrology
|May 22, 2023
Summary
Extra-capillary hypercellularity is a rare finding in diabetic nephropathy (DN). This case study identified epithelial cell proliferation as the origin of this atypical lesion in DN, aiding diagnosis.
Area of Science:
- Nephrology
- Pathology
- Immunohistochemistry
Background:
- Extra-capillary hypercellularity is common in crescentic glomerulonephritis (GN) and focal segmental glomerulosclerosis (FSGS).
- In diabetic nephropathy (DN), it often indicates superimposed conditions like IgA nephropathy or microscopic polyangiitis.
- Rarely, epithelial cell proliferation can occur directly within DN.
Observation:
- A patient with nephrotic syndrome presented with nodular diabetic glomerulosclerosis and significant extra-capillary hypercellularity.
- Serological and immunofluorescence results did not suggest other forms of crescentic GN.
- Immunostaining for claudin-1 and nephrin was used to investigate the source of the extra-capillary lesions.
Findings:
- The study identified epithelial cell proliferation as the cause of extra-capillary hypercellularity in a case of nodular diabetic glomerulosclerosis.
- Immunostaining for claudin-1 and nephrin proved crucial in determining the origin of these atypical lesions.
- The findings support a diagnosis of DN-associated extra-capillary cell proliferation.
Implications:
- Extra-capillary hypercellularity in diabetic nephropathy is a rare but significant finding that requires careful consideration.
- Co-staining for claudin-1 and nephrin can aid in diagnosing this specific manifestation of diabetic nephropathy.
- This approach helps differentiate DN-associated proliferation from other forms of GN.
Keywords:
Crescentic glomerulonephritisDiabetic nephropathyExtra-capillary cell proliferationFocal segmental glomerulosclerosisParietal epithelial cellPodocyteMore Related Videos
Related Concept Videos
01:20Renal Corpuscle
2.9K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
2.9K
01:25Chronic Kidney Disease I: Introduction
48
Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
48
01:10Nephrons
3.1K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
3.1K
01:24Chronic Kidney Disease II: Clinical Manifestations
46
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
46
01:28Chronic Kidney Disease III: Interprofessional Care
54
Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
54
01:24Nephrotic Syndrome I : Introduction
11
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
11