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Preparation of Washed Human Platelets for Quantitative Metabolic Flux Studies
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The Diabetic Platelets.

Suneet Kumar Verma1, Sanjay Kalra2

  • 1Department of Internal Medicine, Alchemist Hospital, Panchkula, India; Sparsh Clinic, Panchkula.

JPMA. the Journal of the Pakistan Medical Association
|May 23, 2023
PubMed
Summary

Diabetes impacts platelet function and morphology. This review covers how glucose-lowering and anti-platelet drugs affect platelets in diabetes management.

Keywords:
Anaemia, aspirin, aspirin resistance, blood, dengue, haematology, hyperglycaemia, platelet.

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Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Hematology

Background:

  • Diabetes mellitus is associated with altered platelet characteristics.
  • Platelet activation and aggregation are increased in individuals with diabetes and its complications.
  • These changes contribute to the heightened thrombotic risk observed in diabetic patients.

Purpose of the Study:

  • To describe platelet morphology and physiology in diabetes.
  • To review the impact of glucose-lowering medications on platelet function.
  • To summarize the role of anti-platelet therapies in managing diabetes.

Main Methods:

  • Literature review of studies on platelet function in diabetes.
  • Analysis of research on glucose-lowering drugs and platelet activity.
  • Synthesis of evidence regarding anti-platelet agents in diabetic individuals.

Main Results:

  • Diabetes is linked to specific changes in platelet size, shape, and reactivity.
  • Certain glucose-lowering drugs demonstrate beneficial effects on platelet function.
  • Anti-platelet medications play a crucial role in mitigating thrombotic events in diabetes.

Conclusions:

  • Platelet abnormalities are a significant feature of diabetes and its complications.
  • Pharmacological interventions targeting glucose control and platelet activity are essential for comprehensive diabetes care.
  • Further research is warranted to optimize anti-platelet strategies in diabetic populations.