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Updated: Jul 29, 2025

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Enantioselective Sulfonium-Claisen Rearrangement with Cinnamyl Thioethers.

Jiwon Jang1, Youngjin Bae1, Seunghoon Shin1

  • 1Department of Chemistry, Research Institute for Natural Sciences and Center for New Directions in Organic Synthesis (CNOS), Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul 04763, Korea.

Organic Letters
|May 23, 2023
PubMed
Summary

Researchers developed a new method for synthesizing skipped 1,4-dienes using cinnamyl thioethers in a gold-catalyzed sulfonium-Claisen rearrangement. This breakthrough achieves high enantioselectivity and yield, enabling access to valuable chiral compounds.

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