Related Experiment Video
Updated: Jul 29, 2025
09:43
Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice
Published on: June 8, 2022
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Pathogenic cellular and molecular mediators in lupus nephritis
Chandra Mohan1, Ting Zhang2, Chaim Putterman3,4
1Department of Biomedical Engineering, University of Houston, Houston, TX, USA. cmohan@central.uh.edu.
Nature Reviews. Nephrology
|May 24, 2023
Summary
Lupus nephritis (LN) affects up to 60% of lupus patients, often leading to kidney failure despite current treatments. New research into LN pathogenesis offers hope for improved therapies targeting kidney disease in systemic lupus erythematosus.
Area of Science:
- Immunology
- Nephrology
- Genomics
Background:
- Kidney involvement, or lupus nephritis (LN), is a common complication of systemic lupus erythematosus, affecting 40-60% of patients.
- Current treatments for LN have limited efficacy, with a significant portion of patients progressing to kidney failure and experiencing severe side effects from therapies like corticosteroids and immunosuppressants.
Purpose of the Study:
- To explore recent advancements in understanding the immune cells, molecules, and pathways involved in lupus nephritis pathogenesis.
- To identify novel therapeutic targets for lupus nephritis based on new insights and human kidney tissue studies.
Main Methods:
- Proteomics
- Flow cytometry
- RNA sequencing
- Analysis of human lupus nephritis kidney tissue
Main Results:
- Advances in high-throughput technologies have provided deeper insights into LN pathogenesis.
- New potential therapeutic targets are emerging from these studies.
Conclusions:
- Understanding the molecular and cellular mechanisms of LN is crucial for developing more effective treatments.
- Emerging therapeutic targets are currently under investigation in preclinical and early clinical studies, aiming to improve outcomes for patients with lupus nephritis.
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